A Comprehensive Drug Safety Evaluation of Pregabalin in Peripheral Neuropathic Pain
نویسندگان
چکیده
منابع مشابه
A Comprehensive Drug Safety Evaluation of Pregabalin in Peripheral Neuropathic Pain
Pregabalin is a commonly used therapy currently recommended as first-line treatment for a number of neuropathic pain (NeP) conditions. Since licensure, a number of clinical trials of pregabalin in different NeP conditions have been completed from which additional data on safety and tolerability can be drawn. In this analysis, patient-level data from 31 randomized clinical trials of pregabalin i...
متن کاملRetraction: Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states
BACKGROUND Although pregabalin therapy is beneficial for neuropathic pain (NeP) by targeting the CaVα2δ-1 subunit, its site of action is uncertain. Direct targeting of the central nervous system may be beneficial for the avoidance of systemic side effects. RESULTS We used intranasal, intrathecal, and near-nerve chamber forms of delivery of varying concentrations of pregabalin or saline delive...
متن کاملMeta-analysis of duloxetine vs. pregabalin and gabapentin in the treatment of diabetic peripheral neuropathic pain
BACKGROUND Few direct head-to-head comparisons have been conducted between drugs for the treatment of diabetic peripheral neuropathic pain (DPNP). Approved or recommended drugs in this indication include duloxetine (DLX), pregabalin (PGB), gabapentin (GBP) and amitriptyline (AMT). We conducted an indirect meta-analysis to compare the efficacy and tolerability of DLX with PGB and GBP in DPNP, us...
متن کاملComparative study of efficacy and safety of pregabalin and gabapentin in neuropathic pain
Neuropathic pain differs from nociceptive pain by their causation, character and also mode of treatment. Most neuropathic pain responds poorly to non steroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics. Pregabalin and gabapentin have been extensively studied in the treatment of neuropathic pain but there is no evidence to indicate superiority of one of these drugs above the other. ...
متن کاملPredictors of placebo response in peripheral neuropathic pain: insights from pregabalin clinical trials
BACKGROUND Greater understanding of factors associated with the high placebo-response rates noted in recent neuropathic pain trials may improve trial design. This study investigated placebo response and its predictors in pregabalin trials in patients with diabetic peripheral neuropathy (DPN) or postherpetic neuralgia. PATIENTS AND METHODS Individual patient data from 16 randomized, placebo-co...
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ژورنال
عنوان ژورنال: Pain Practice
سال: 2013
ISSN: 1530-7085,1533-2500
DOI: 10.1111/papr.12146